Fabio Aprile - INFN - Bari
Geometry and Relaxation Dynamics of Nematic Loops 
Disclination lines in three-dimensional nematic liquid crystals generically form closed loops whose topology is classified by homotopy theory. While this classification successfully captures global topological features, it does not encode the geometry of the defect profile along the loop, which can strongly influence defect dynamics. Here, we propose a geometric description of nematic disclination loops using the Clifford algebra $\mathrm{Cl}(3,0)$. This approach naturally captures the geometry of the local defect profile, as well as changes along the loop, which is mathematically a $\mathrm{SU}(2)$ holonomy. Simulations of the dynamics of defect loops with specified geometries embedded in nematic liquid crystals demonstrate that loops nucleate the growth of "topological blobs" of defects, which later dissipate leaving uniform nematic textures. Self-twist of the defect profile leads to nucleation of additional linking disclination lines, with a simple arithmetic relation between total self-twist and linking number. In contrast, loops with an even number of discrete profile transitions generate patterns with threading between loops, but no linking.
These results establish a direct connection between the geometric holonomy of a disclination loop and its subsequent evolution, and may be extendable to more complex order parameter manifolds, such as cholesterics or smectics. |
Paolo Baglioni - INFN - Milano Bicocca
Kernel shape renormalization explains output-output correlations in finite Bayesian one-hidden-layer networks 
Finite-width one hidden layer networks with multiple neurons in the readout layer display non-trivial output-output correlations that vanish in the lazy-training infinite-width limit. We leverage recent progress in the proportional limit of Bayesian deep learning (that is the limit where the size of the training set P and the width of the hidden layers N are taken to infinity keeping their ratio P/N finite) to rationalize this empirical evidence. In particular, we show that output-output correlations in finite fully-connected networks are taken into account by a kernel shape renormalization of the infinite-width NNGP kernel, which naturally arises in the proportional limit. We perform accurate numerical experiments both to assess the predictive power of the Bayesian framework in terms of generalization, and to quantify output-output correlations in finite-width networks. By quantitatively matching our predictions with the observed correlations, we provide additional evidence that kernel shape renormalization is instrumental to explain the phenomenology observed in finite Bayesian one hidden layer networks. |
Simon Böhly - University of Padova
Probing universal relaxation speed in a Bose-Einstein condensate far from equilibrium 
The dynamics of a Bose-Einstein condensate initialized in a far-from-equilibrium state can exhibit behavior that is reminiscent of fixed points in phase transitions—namely, self-similar scaling and universality. This phenomenon is referred to as a “non-thermal fixed point”. The properties of non-thermal fixed points enable predictions about the system’s relaxation dynamics, particularly the speed at which relaxation occurs. Dimensional analysis suggests that the relaxation speed exhibits universality—that is, counterintuitively, it does not depend on microscopic details such as the condensate’s density or interaction strength or on the exact initial state. Recent experimental results support this prediction (arXiv:2410.08204 [cond-mat.quant-gas]). In this poster, I will first introduce the concept of non-thermal fixed points and their connection to relaxation dynamics. I will discuss results based on numerical simulations and analytical approaches, addressing the question: “To what extent is the relaxation speed in a far-from-equilibrium Bose-Einstein condensate universal?”
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Francesco Bonilauri - University of Parma
Dynamical Mean Field Theory of Sparse Inhibitory-Excitatory Networks 
A realistic model of a real world biological neural network would need to be both sparse and comprised of separate inhibitory and excitatory neuron populations. While dynamical mean field theory (DMFT) approaches exist separately for networks in the very sparse regime (degree $c \ll N$) and for diluted I-E networks, in our work we combine the two, using a population dynamics algorithm to sample the mean field path probability of very sparse I-E networks. We find that this approach correctly predicts the neuron currents, whereas the gaussian approximation fails. Moreover, this approach makes no assumptions about the degree distribution, and we show that even in the high connectivity limit $c \to \infty$, the network is affected by the degree fluctuations of an inhomogeneous distribution, diverging from the usual dense gaussian theory. |
Lorenzo Buffoni - Università degli Studi di Firenze
Exact Fixed-Point Constraints in Neural-ODEs with Provable Universality 
We introduce a technique that enables Neural-ODEs to approximate arbitrary velocity fields with a priori planted fixed-points. Specifically, a recipe is given to explicitly accommodate for a finite collection of points in the reference multi-dimensional space of the Neural-ODE where the velocity field is exactly equal to zero. In this way, the gradient-based training is rigorously constrained inside the prescribed hypothesis class while leaving the expressive power of the Neural-ODE unaltered. We rigorously prove the universality of the Neural-ODE under any local constraints in the velocity field and give a computationally convenient way of imposing the fixed points, testing it on two paradigmatic physical models. |
Gianmarco Cafaro - Università degli Studi di Salerno
Temporal Organization of Neuronal Avalanches Constrained by Structural Connectivity in MEG 
The study of neuronal activity through electrophysiological recordings provides a framework to investigate brain function and how biological alterations may influence disease onset. Different analytical approaches across multiple brain scales (single neurons, neural networks, neural mass, and whole-brain activity) yield distinct biomarkers, offering insight into where and how system-level disruptions emerge in specific pathologies. Neuronal avalanches, consistently observed across these scales, suggest that brain dynamics operate near a critical point, leading to the emergence of scale-free distributions in both the size of recorded activity and the duration of bursts of coordinated activations. The occurrence of simultaneous activations across multiple neuronal components (e.g., brain regions in whole-brain analyses) correlates with the underlying connectivity among these components, providing a natural interpretation in terms of network interactions grounded in biologically measurable architectures. However, how neuronal activity, organized into avalanches, is structured in time—particularly in relation to the sequence of brain states (microstates) that the system traverses—and how the topological properties of brain architecture shape this temporal organization remain open questions. In this study, we analyzed magnetoencephalography (MEG) recordings from 30 healthy male and female subjects with no certified neurological disorders, during eyes-closed resting-state activity, within the framework of neuronal avalanche analysis. We find that the size of burst activations (defined as the integrated signal above threshold across all active brain regions during a bursting event) and the inter-avalanche silent time are not independent variables. The joint probability distribution of avalanche size conditioned on a given preceding silent time was estimated and compared with a reshuffled surrogate dataset, revealing significant temporal correlations. In particular, small avalanches are more likely to follow long silent periods, whereas large avalanches preferentially follow short silent intervals. These results provide the opportunity to distinguish between small- and large-size avalanches. We
find that brain regions with higher white matter node degree connectivity are more likely to be active during small avalanches, whereas less connected regions require higher levels of activity to be recruited. This suggests that the underlying structural connectivity plays a role in shaping the temporal and spatial organization of avalanche dynamics. |
Michele Campisi - Istituto nanoscienze CNR - Pisa
Unified Theory of Classical and Quantum Ergotropy 
Quantifying the ergotropy (a.k.a. available energy), namely the maximal amount of energy that can be extracted from a thermally isolated system, is a central problem in quantum thermodynamics. Notably, the same problem has been long studied for classical systems as well, e.g. in plasma physics and astrophysics, where the basic principles for its solution are known for the case of collisionless fluids. Here we provide the general analytical expression of ergotropy of classical systems valid regardless of their size and the type of interparticle interactions, and show that it emerges as the classical limit of the quantum expression of ergotropy, for quantum systems that are classically ergodic. We thus establish a unified theory of classical and quantum ergotropy, whose applicability ranges from atomic to galactic scale.
www.doi.org/10.1209/0295-5075/ae652c
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Lorenzo Capra - Università degli Studi di Siena
Ricerca e generalizzazione di Stati Quasi-"Absolutely Maximally Entangled" tramite Entanglement Distance 
La caratterizzazione dell'entanglement in sistemi multipartiti ad alta dimensionalità rappresenta una sfida cruciale nell'ambito dell'informazione quantistica. In questo contributo si discute l'Entanglement Distance, una misura di correlazione quantistica basata sulla geometria dello spazio di Hilbert, analiticamente trattabile per stati puri arbitrari. Sfruttando la sua invarianza rispetto alla dimensionalità delle partizioni, l'Entanglement Distance viene impiegata per calcolare analiticamente il valore medio di entanglement per un ensemble di stati generati casualmente secondo la misura di Haar. Partendo da questi risultati esatti, si introduce un algoritmo variazionale mirato alla ricerca di stati quasi Assolutamente Massimamente Entangled (AME) per sistemi di dimensione arbitraria. Oltre a esibire proprietà di correlazione statisticamente superiori rispetto ai tipici Haar random states, gli stati ottimizzati ottenuti tramite questo approccio presentano una spiccata sparsità (ovvero un numero ridotto di componenti e ampiezze di probabilità non nulle nella base computazionale). Quest'ultima caratteristica teorica si traduce in un vantaggio tecnologico cruciale, poiché ne facilita significativamente la preparazione e l'implementazione su hardware quantistici reali, riducendo la complessità dei circuiti di controllo. |
Fabio Cecconi - CNR-Istituto dei Sistemi Complessi
Beating Dynamics of Semiflexible Flagella Under Traveling-Wave Perturbations 
Flagella and cilia play a crucial role in microscale fluid dynamics, powering the motion of cells and driving flows in biological systems. In this talk, we present a theoretical framework to understand how semiflexible filaments respond to traveling-wave perturbations that mimic the action of molecular motors. By modeling the flagellum as a worm-like chain (WLC), we explore the competition between active forcing and intrinsic bending rigidity, revealing how this interplay selects spatiotemporal beating patterns akin to those observed in sperm tails, Chlamydomonas cilia, and eukaryotic flagella in general. Through a systematic analysis of the WLC's response, we identify the key physical parameters that shape flagellar motion and discuss their implications for biological propulsion and artificial microswimmers. Our findings offer a simple mathematical interpretation of the fundamental elements governing active filament dynamics in complex fluid environments. |
Paolo Lapo Cerni - Università di Padova
Emergence of hierarchical modularity in empirical interconnected systems 
Hierarchical modularity is a ubiquitous feature of complex systems, from biological and neural networks to social and technological infrastructures, yet the general physical principle underlying its emergence remains unclear. Here we show that hierarchical interactions can arise as the optimal architecture for multiscale information processing in sparse interconnected systems. Using the network density matrix formalism, we define a scale-dependent thermodynamic efficiency that quantifies the trade-off between information transport, dynamical trapping, and response diversity across propagation scales. We then introduce an integrated efficiency, obtained by aggregating this quantity over all scales, as a macroscopic variational principle for network organization. Analytical arguments and numerical experiments show that hierarchical modular architectures maximize integrated efficiency. Therefore, such architectures are not merely a descriptive hallmark of complexity, but the emergent outcome of a general information-thermodynamic optimization principle governing multiscale dynamics in complex systems. |
Lorenzo Chicchi - Università di Firenze
Learning with Attractors: A Dynamical Systems Approach to Classification and Generation 
In recent years, machine learning has achieved remarkable success, yet many of its models remain difficult to interpret. In this talk, I present an alternative perspective in which learning is formulated in terms of dynamical systems with explicitly designed attractors. Within this framework, data are treated as initial conditions of a continuous-time evolution, and classification emerges from the asymptotic state reached by the system. Each class is associated with a stable attractor, and learning amounts to shaping the interactions so that trajectories converge to the appropriate equilibrium.
Moreover, the introduction of stochasticity transforms deterministic attractors into probability distributions, providing a direct link to generative modeling. The same dynamical system can therefore be used not only to classify data, but also to generate new samples by exploiting the structure of the learned attractors.
This framework offers a transparent and physically grounded interpretation of learning processes, where information is encoded in the geometry of the dynamical landscape. I will discuss recent results and outline how this perspective may contribute to bridging machine learning and theoretical physics. |
Guido Cimino - Sapienza - Università di Roma
Spin-Waves without Spin-Waves: A Case for Soliton Propagation in Starling Flocks 
Collective turns in starling flocks propagate linearly with negligible attenuation, indicating the existence of an underdamped sector in the dispersion relation. Beside granting linear propagation of the phase perturbations, the real part of the frequency should also yield a spin-wave form of the unperturbed correlation function. However, new high-resolution experiments on real flocks show that underdamped traveling waves coexist with an overdamped Lorentzian correlation. Theory and experiments are reconciled once we add to the dynamics a Fermi-Pasta-Ulam-Tsingou term. |
Giuseppe Consolini - Istituto Nazionale di Astrofisica
A Possible Observational Evidence of Bolgiano-Obukhov Scaling in a Natural Buoyancy-Driven Turbulent System 
G. Consolini (1), E. Papini (1) and R. Benzi (2)
1) INAF-Istituto di Astrofisica e Planetologia Spaziali, Roma, Italy
2) Dip. Di Fisica, Univ. Roma Tor Vergata, Roma, Italy
The Bolgiano-Obukhov (BO) theory of buoyancy-driven turbulence has remained without clear experimental confirmation in any real natural system for over six decades. Here, we report a possible first observational evidence of BO scaling obtained from electric field fluctuations measured inside equatorial ionospheric plasma bubbles by the CSES-01 satellite, used as a proxy for the underlying plasma velocity field. Analysing the second-order structure function across three independent events, we identify a well-defined dual turbulent regime and a characteristic scale, the Bolgiano scale L_B: below L_B, fluctuations follow Iroshnikov-Kraichnan MHD scaling consistent with Alfvénic turbulence, while above L_B the r^(6/5) power law characteristic of BO convective turbulence emerges unambiguously. The onset of BO scaling is observed in the quasi-two-dimensional geometry of plasma bubbles at late evolutionary stages, when magnetic field alignment stretches them into elongated structures with aspect ratios of order 0.01–0.04. Rescaling by L_B produces a remarkable data collapse across all three events, pointing to a universal turbulent behavior governed by the bubble geometry and revealing a quasi-exponential relation between L_B and the transverse size of the structure. |
Davide Conte - Università degli Studi della Campania "Luigi Vanvitelli"
Towards a Predictive Physics-Based Framework for Foreshocks: Moving Beyond Hindsight Bias in Seismic Forecasting. 
Statistical seismology classifies earthquakes into three main categories: mainshocks, foreshocks, and aftershocks. A mainshock is typically defined as the largest earthquake within a seismic sequence or region, aftershocks are the events triggered by it, and foreshocks are the earthquakes that occur before the mainshock. This definition immediately highlights a fundamental problem: unlike aftershocks, foreshocks can only be identified retrospectively, once the mainshock has already occurred. As a result, it remains unclear whether foreshocks carry genuine predictive information or simply reflect ordinary seismic clustering viewed in hindsight.
The Epidemic-Type Aftershock Sequence (ETAS) model is the standard framework used to describe seismicity as a branching process in which earthquakes trigger subsequent events. Although ETAS successfully reproduces many features of aftershock clustering, it systematically underestimates the number of foreshocks observed in real seismic catalogs and does not provide a physical mechanism for earthquake nucleation.
To address this limitation, we introduce the ETAS-BC model, an extension of ETAS in which earthquakes can generate magnitude-ordered chains of “connector” events that progressively activate the fault system and culminate in a mainshock. Within this framework, foreshocks emerge as the manifestation of a preparatory process rather than as a purely retrospective classification. The model remains analytically tractable, allowing us to derive predictions for the magnitude distribution, productivity, and spatio-temporal organization of connector sequences.
Comparison with Southern California seismicity shows that ETAS-BC reproduces the observed number of foreshocks significantly better than standard ETAS while preserving its successful description of aftershock statistics. These results suggest that introducing connector-driven nucleation processes provides a promising physics-based framework for describing earthquake preparation and improving statistical models of seismicity. |
Debraj Das - SISSA
Run-and-tumble exact work statistics in a lazy quantum measurement engine: Stochastic information processing 
We introduce a single-qubit quantum measurement engine powered by backaction energy input. This engine utilizes the fundamental principles of quantum measurement and feedback to harness work from the system. To reduce the energetic costs associated with information processing, we propose a lazy feedback mechanism. The lazy feedback step stochastically utilizes measurement outcomes, prescribed by a designated laziness probability. As a result, the cumulative work extracted over successive cycles of the engine exhibits a second-order Markov process, analogous to a classical run-and-tumble process with transient anomalous diffusion. We derive exact analytical expressions for finite-time moments of the extracted work and key statistical measures, including first-passage-time distributions. Furthermore, we obtain the optimal laziness probability that maximizes the mean power extracted per cycle from the quantum engine. All analytical results on the extracted work are readily applicable to the run-and- tumble process, for which obtaining first-passage-time distributions is highly nontrivial. Our work thus highlights hitherto-unexplored links between quantum engine and active matter. |
Antonio de Candia - Università di Napoli Federico II
Symmetry breaking and avalanche shapes in modular neural networks 
Experimental evidence suggests that the healthy brain operates near a critical regime, characterized by scale-free neuronal avalanches. Recent research has increasingly focused on the mean temporal profiles of neuronal avalanches, as a more stringent and reliable test for criticality. Scaling arguments predict that, when appropriately rescaled, the mean temporal profiles of avalanches of widely varying durations should collapse onto a single scaling function, often approximated by an inverted parabola. Experimental measurements have revealed clear departures from perfect symmetry, often displaying leftward skewing and extended tails. We have investigated the stochastic Wilson–Cowan model on a modular network, in which synaptic strengths differ between intra-module and inter-module connections. The system exhibits a rich phase diagram, comprising symmetric and "broken symmetry" phases. We found that, at the edge of the transition to a symmetric phase, avalanches are right-ward skewed, as observed also in the non-modular Wilson–Cowan model. On the other hand, at the transition to a "broken symmetry" phase, avalanches become left-ward skewed. We found that in the latter case avalanches proceed in two stages: an initially cooperative regime, where excitatory activity is prevalent, followed by inhibitory competition that selects one dominant module and suppresses the others. This is the relevant mechanism leading to a fast rise of the avalanche, followed by a slower decay, and therefore to leftward asymmetry. These findings contribute to a better understanding of the relationship between brain network topology and functional brain activity. |
Elisabetta Elettari - University of Parma
Rare Events and Redundancy in Random Walkers Target Search in a Finite Domain 
Finding a target in a complex environment is a fundamental challenge across natural systems, from chemical reactions to sperm cells reaching an egg. One powerful strategy to reduce search times is redundancy: deploying multiple independent searchers increases the probability of success, particularly when this is driven by rare events. When the underlying stochastic motion features broadly distributed step lengths, rare long relocations dominate the dynamics, making redundancy especially effective.
In this work, we investigate the statistics of extreme events for the mean first passage time in a system of $N$ independent walkers performing power-law-distributed jumps with finite velocity $v$, where target-reaching events are governed by single large fluctuations. We show that the mean first passage time of the fastest walker scales as $1/N$, representing a dramatic speed-up compared to classical Brownian motion, and saturates at the minimum value $X/v$. The model is further extended to include random velocities.
For a fixed $N$, we identify a crossover governed by a critical tail exponent $\alpha_c$, which separates a regime dominated by a single large fluctuation ("big jump") from a regime characterized by Gaussian extreme-value statistics arising from finite sampling effects. From these results, a scaling law linking the number of searchers $N$ to the size $X$ of the search region is derived.
Ultimately, these findings demonstrate how redundancy, combined with rare-event statistics, can efficiently organize target-search processes in complex biological environments. As a prototypical application, we consider mammalian fertilization, deriving a cross-species scaling relation between the number of spermatozoa and the typical uterine size within a coarse-grained description. |
Andrea Fontana - Università di Napoli "Federico II" e INFN Napoli
Physical principles of phase-separation action on DNA folding associated to aberrant gene activation 
Phase-separation of chimeric proteins resulting from genetic mutations has been shown to trigger aberrant chromatin looping, contributing to disease development, including cancer [1]. However, the physical mechanisms regulating these processes remain unclear. In this study, we employ polymer physics models of chromatin [2] to investigate the relationship between protein self-aggregation and chromatin structure [2]. We show that a simple model, including only protein-protein and protein-chromatin interactions, effectively explains the aberrant looping around certain oncogenes in cells expressing the NUP98-HOXA9 chimera [1], commonly found in leukemia. Moreover, when incorporating the presence of cohesin in a more complex model [3], similar results are observed, suggesting a weak dependence of these looping mechanisms on loop-extrusion. Finally, leveraging our molecular dynamics simulations, we compare our findings with experimental data [1] and show that phase-separation properties of the chimera can be harnessed to prevent enhancer-gene contacts, thereby offering a potential strategy for cancer prevention [3].
[1] J. H. Ahn et al., “Phase separation drives aberrant chromatin looping and cancer development”. Nature 595, 591-595 (2021).
[2] A. M. Chiariello, F. Corberi, M. Salerno, “The Interplay between Phase Separation and Gene-Enhancer Communication: A Theoretical Study”. Biophys. J. 119, 873-883 (2020).
[3] Guha, Fontana et al., “Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding”. bioRxiv (2025). |
Pierpaolo Fontana - University of Trieste
Renormalized dual basis for scalable simulations of higher dimensional lattice gauge theories 
We present the Renormalized Dual Basis (RDB), a scalable and resource-efficient framework for the classical and quantum simulation of lattice gauge theories (LGTs) with continuous gauge groups in higher dimensions. The method combines a dual formulation of the theory with a local optimization of the gauge basis, obtained from the solution of the single-plaquette problem, enabling an efficient truncation of the infinite-dimensional Hilbert space of gauge degrees of freedom. We apply the approach to both Abelian and non-Abelian LGTs in two spatial dimensions, focusing on compact quantum electrodynamics (cQED) and pure SU(2) gauge theories. For small lattices with periodic boundary conditions in the pure gauge case, and open boundary conditions in the presence of fermionic matter, we determine the ground state properties of the theory and compute gauge-invariant observables such as the plaquette expectation value. Compared to standard truncation schemes, the RDB achieves improved accuracy while requiring significantly fewer local basis states across all coupling regimes. To assess the scalability of the method, we further investigate larger lattice systems using tensor network algorithms. These results demonstrate that the RDB remains efficient as the system size increases, without a dramatic growth in computational resources. |
Enrico Fornasa - SISSA
Self-assembly Monte Carlo reveals localized entanglement in giant polymer melts 
Topological entanglements are central to understanding and predicting the properties of polymer melts. Yet, they make equilibrium sampling computationally challenging, as decorrelation times grow rapidly with chain length. Here, we introduce a Monte Carlo scheme that bypasses typical computational bottlenecks by working in a self-assembly ensemble rather than at fixed composition. Strictly local moves efficiently propagate backbone reconnections across scales while conserving the number of linear chains, achieving near-linear scaling of decorrelation time with system size, τeq~ Vˆ1.0. With this method, formulated for a fully-packed lattice, we equilibrate periodic systems totalling up to≃ 1.1 × 10ˆ9 monomers, accessing a universal melt regime insensitive to lattice details. We analyze intra- and inter-chain entanglements for chains of up to N ≃ 5 × 10ˆ5 monomers, revealing that they manifest as localized knots and links rather than as global tangles. Finally, we show that the magnitude of the Gauss linking integral between neighbouring chains grows only as Nˆ1/4. |
Andrea Gabrielli - Università degli Studi "Roma Tre"
Topological Symmetry Breaking in Antagonistic Dynamics 
Engineered systems with antagonistic interactions remain comparatively unexplored, particularly because their emergent phases are closely linked with frustration mechanisms in the hosting network. In this context, the spin glass theory has shown how an apparently uncontrollable non-ergodic chaotic behavior arises from the complex interplay of competing interactions and frustration among units, leading to multiple metastable states preventing the system from exploring all accessible configurations over time.
Here, we show how topology constrains dynamics in systems with antagonistic interactions. We make use of the signed Laplacian operator to demonstrate how fundamental topological defects in lattices and networks percolate, shaping the geometrical arena and complex energy landscape of the system. This unveils novel, highly robust multistable phases and establishes deep connections with spin glasses when thermal noise is considered, providing a natural topological and algebraic description of emergent multistability and non-ergodicity in frustrated systems. |
Andrea Gamba - Politecnico di Torino
Enzyme-driven phase separation 
The formation of polarized signaling domains on cell membranes is a fundamental example of biological pattern formation. While such patterns resemble structures from equilibrium phase separation, they are intrinsically non-equilibrium, driven by energy-consuming enzymatic cycles that switch molecules like phosphoinositides or small GTPases between distinct states. We develop a minimal model of this enzyme-driven phase ordering process. Starting from microscopic reaction kinetics, we derive a mesoscopic theory that belongs to the class of active Model A with a global constraint. This framework yields an explicit mean-field phase diagram and closed-form expressions for key observables, such as interfacial tension, domain fractions, and phase coexistence boundaries, in terms of kinetic rates. In this context, phase coexistence is controlled by non-equilibrium parameters like catalytic rates and enzymatic asymmetry, rather than equilibrium parameters such as saturation concentrations. The resulting phase-separated domains rapidly exchange material with their surroundings. Their maintenance requires a continuous power input determined by enzymatic kinetics. The predicted phenomenology is consistent with experimental observations on reconstituted systems of phosphoinositide and Rab5 membrane patterning. We further study how metastable uniform states decay via nucleation of minority-phase domains and subsequent coarsening, driven by an effective interfacial tension. Using large deviation theory, we derive the critical nucleation radius under the action of the intrinsic, multiplicative chemical noise. The analytical results are quantitatively confirmed by stochastic simulations of a lattice-gas implementation of the process. Our work provides a theoretical framework identifying key biochemical parameters controlling active phase separation on membrane scaffolds, offering testable predictions for experiments.
References
https://arxiv.org/abs/2512.08356 |
Jacopo Alexander Garofalo - Universita della Campania Luigi Vanvitelli
Janus Percolation in Anisotropic Limited-Degree Networks 
Many real-world infrastructures, from sensor and road networks to power grids, are spatially
embedded and anisotropic, with constraints on the maximum number of links each node can establish. Such systems can be represented as anisotropic limited-degree networks, in which each node forms at most q outgoing links preferentially oriented along a fixed direction. By increasing the node density σ at fixed q, we uncover a reentrant percolation transition: a giant strongly connected component emerges, but unexpectedly disintegrates again at high densities. This counterintuitive behavior implies that adding nodes, normally expected to enhance robustness, can instead reduce mutual accessibility and weaken global connectivity. The critical behavior displays two coexisting “faces”: random-percolation scaling along the preferred direction and directed-percolation scaling transversely,
therefore we name this phenomenon Janus percolation, in analogy with the dual-faced Roman god. These findings demonstrate that anisotropy and degree limitation can jointly induce a novel reentrant connectivity with mixed universality that bridges the universality classes of random and directed percolation, providing fresh insight into how structural constraints shape connectivity and resilience in spatial networks. |
Guido Giachetti - Ecole Normale Superieure, Paris
Integrable Dynamics and Thermalization in the Quantum O(n) Model at Large n 
The quantum $O(n)$ model has long served as a valuable framework for studying both equilibrium and dynamical properties of quantum many-body systems. In this talk, we investigate its non-equilibrium dynamics following a quantum quench in the large-$n$ limit. While the model is known to be tractable in this regime, we show that it is in fact integrable - with integrals of motions stemming from that of the classical Neumann model - thus enabling a complete analytical solution of its dynamics. This integrability reveals a synchronization mechanism that gives rise to persistent oscillations, interpretable as Higgs modes localized at the edge of the spectral band. We further demonstrate that the long-time behavior is governed by a Generalized Gibbs Ensemble (GGE), in contrast to previous expectations, and we obtain exact critical exponents differing from those commonly reported. Remarkably, integrability persists even in the presence of long-range couplings, allowing us to explore the crossover between mean-field and genuinely many-body regimes in terms of parametric Floquet resonances of the microscopic degrees of freedom. |
Stefano Iubini - Istituto dei Sistemi Complessi CNR - Sesto Fiorentino
Thermodynamics of photonic nonlinear Aharonov-Bohm cages 
We investigate the thermodynamic and non-equilibrium properties of an open nonlinear diamond lattice under the influence of a uniform magnetic field. The chain exhibits two dispersive bands and one zero-energy flat band. By fine-tuning the magnetic flux, all three Bloch bands turn flat, resulting in Aharonov-Bohm caging and the total suppression of particle and energy currents. The equilibrium phase diagram is obtained as function of the flux. By driving the system at the boundaries with two thermostats, we study the transport of norm and energy across the system for different flux values and nonlinear strengths. For weak nonlinearity, the caging condition turns the system into an insulator, while the system is ''metallic'' for all other flux values. For intermediate nonlinear strength instead, the system behaves as a conductor for any flux value. However, in this regime the caging condition enhances Seebeck coefficient and the figure of merit, improving the thermoelectric features of the chain. These results highlight the magnetic flux as a versatile control parameter for effectively tuning the thermodynamic and transport signatures of the system. |
Paolo La Francesca - Università degli studi Roma Tre
Liquid-Liquid Critical Point, Dynamics and Structure of Aqueous Solutions of Perchlorates: a Molecular Dynamics Study 
We employ molecular dynamics (MD) simulations to determine how magnesium perchlorate
(Mg(ClO4)2) and calcium perchlorate (Ca(ClO4)2) alter the phase diagram, structure, and dy-
namics of supercooled TIP4P/2005 water. We focus on the interplay between its low-density
(LDL) and high-density liquid (HDL) phases and the glassy dynamics, simulating solutions at
concentrations from low to moderate. Thermodynamic analysis confirms the persistence of water anomalies, albeit shifted by the solutes. A second-order liquid-liquid critical point (LLCP) was located at low concentrations, but not at moderate concentrations within the simulated temperature range. Dynamically, similar to the bulk, water in these solutions follows the Mode Coupling Theory, exhibiting a fragile-to-strong crossover. Structurally, radial distribution functions demonstrate that increasing solute concentration enhances HDL-like behaviours and suppresses LDL ordering, the nucleation being favoured in LDL water. This correlates with a marked contraction of the LDL-like region in the (p, T) phase diagram, inferred from compressibility maxima shifts, which serve as a proxy for the maxima of the HDL-LDL correlation length. In light of recent potential radar evidence for aqueous solutions of perchlorates approximately 1.5 km underneath Mars’ south pole, it is of importance to assess their low-temperature stability and the possible crucial role of water anomalies in this context. |
Luca Leuzzi - CNR-NANOTEC
Dense Hopfield models mapping photonic interferometry 
We introduce, develop, and investigate a connection between multiphoton quantum interference, a core element of emerging photonic quantum technologies, and Hopfield-like Hamiltonians of classical neural networks. Combining a system composed of indistinguishable photons in superposition over a set of field modes, a controlled array binary phase-shifters, and a linear-optical interferometer, we can show that the output photon statistics can be described by means of a p-body Hopfield Hamiltonian. We exemplify the analysis of the generalized 4-body Hopfield model obtained through this procedure and show that it realizes a transition from a memory retrieval to a memory black-out regime, i.e. a spin-glass phase, as the amount of stored memory increases. The mapping enables novel routes to the realization and investigation of disordered and complex classical systems via photonic quantum simulators, as well as the description of aspects of structured photonic systems in terms of classical spin Hamiltonians.
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Carlo Lucibello - Bocconi University
Memorization and generalization in generative diffusion under the manifold hypothesis 
We study the memorization and generalization capabilities of a generative diffusion model in the case of structured data defined on a latent manifold. We specifically consider a set of P data points in N dimensions lying on a latent subspace of dimension D, according to the hidden manifold model. Our analysis considers a generative reverse process given by the empirical score function as a proxy of the true one, and then precisely characterizes the process in the high-dimensional limit, by exploiting a connection with the random energy model (REM). We provide evidence for the existence of an onset time, when traps appear in the time-varying potential, although they do not affect typical trajectories. The size of the basins of attraction of such traps is computed at any time. Moreover, we derive the collapse time, at which trajectories fall in the basin of one of the training points, implying memorization. We show that the curse of dimensionality issue is mitigated for highly structured data, i.e. the relevant dimension governing the time at which memorization happens is the intrinsic dimension D instead of the ambient dimension N.
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Salvatore Micciche - UNIPA - Dipartimento di Fisica e Chimica - Emilio Segrè
Geolocalized mafia homicides in Palermo (1950–2020): insights into the evolution of Cosa Nostra 
We investigate the statistical properties of mafia-related homicidal events
occurred in the city of Palermo (Italy) from 1950 to 2020. Such data are
extracted from a unique electronic archive containing microdata on mafia-related
homicides, attempted homicides and disappearances committed in Sicily. This
electronic archive is maintained by the Palermo Prosecutor’s Office (Direzione
Distrettuale Antimafia) and is regularly consulted by magistrates investigating
crimes associated with Cosa Nostra.
Specifically, we aim to understand how geolocalizing homicides within the greater
Palermo area can assist researchers and law enforcement authorities (Judiciary
and Law Enforcement Agencies) in better characterizing and potentially pre-
dicting the temporal (micro-)patterns of crimes perpetrated by Cosa Nostra
syndicates.
To this end, we combine homicidal microdata with population density data at the submunicipal level of neighbourhoods (quartieri). This integration allows us
to identify areas where the incidence of homicides is significantly higher or lower
than expected under a null hypothesis of random distribution, adjusted for the
actual population density in Palermo. In this way, we highlight neighbourhoods
disproportionately affected by homicidal events, not in absolute terms, but rel-
ative to local population figures during a certain time period. The time periods
we are considering are obtained by using an unsupervised statistical procedure
that is able to highlight the temporal points when the statistical properties of
the homicidal time series changes its statistical properties. The underlying idea
is that such changes are associated to a regime shift in the Cosa Nostra criminal
activities.
The analyses presented in this paper may be usefully employed, at the very least,
to reconstruct the broader context in which homicides occur.
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Giuliano Migliorini - University of Padua
Diffusion and enzymatic reactions in crowded solutions 
Biochemical reactions in living systems are affected by macromolecular crowding, a phenomenon
attributed to excluded volume effects and nonspecific interactions, yet these reactions are usually
studied in dilute solutions. Here, we investigate crowding effects on the activity of some key
enzymes found in the extracellular matrix (ECM), such as elastase and collagenase, using
controlled solutions of the branched polymer dextran.
Dextran solutions are characterized via rheology and diffusion measurements. Polymer transport
properties exhibit scaling-invariant behavior governed by degree of polymerization and branching,
whereas water diffusivity and solution density do not depend on the degree of polymerization.
These results enable the construction of volume fractions tailored to the physical observable of
interest.
The enzymatic activity of ECM proteases is quantified through spectrophotometric assays. We
introduce a theoretical framework for fluorescence detection in non-ideal mixtures and apply it to
the full progress curve assays of key ECM enzymes. For elastase, the degradation of a peptide is
enhanced by crowding and reveals an equilibrium constant exhibiting the same scaling behavior as
dextran transport properties, suggesting polymer size and topology as tunable parameters in
crowding experiments. |
Stefano Mossa - CEA Grenoble
Thermal Transport Beyond Classical Green-Kubo: A Path Integral Monte Carlo Approach 
Understanding heat transport in insulating solids at low temperature poses a fundamental challenge in statistical physics, where classical approaches based on Green–Kubo (GK) theory and molecular dynamics fail to capture quantum effects, while semi-classical corrections remain inherently perturbative. Here, we revisit thermal conductivity from a unifying statistical-mechanical perspective, contrasting three levels of description: (i) classical GK calculations, (ii) classical dynamics supplemented by quantum statistical weights (e.g. quantum specific heat corrections), and (iii) fully quantum formulations based on many-body equilibrium correlations.
Building on the framework introduced in [1], we present a non-perturbative approach combining Path Integral Monte Carlo (PIMC) simulations with linear-response theory. Within this formulation, transport coefficients are expressed in terms of imaginary-time current–current correlation functions, which encode the full quantum statistics of the system. The central technical challenge, recovering real-time transport from imaginary-time data, is addressed via controlled analytical continuation, guided by physically motivated priors for the spectral density.
This approach allows us to go beyond the standard Peierls–Boltzmann and quasi-harmonic GK pictures, which rely on phonon lifetimes and fail to describe the low-temperature increase of thermal conductivity. Instead, we demonstrate the emergence of a distinct transport lifetime, directly extracted from current correlations, highlighting the breakdown of single-particle (phonon) descriptions of heat transport. The methodology provides a consistent statistical-mechanical framework in which equilibrium quantum fluctuations, encoded in imaginary time, determine dynamical transport properties.
More broadly, this work illustrates how modern quantum Monte Carlo methods, combined with spectral reconstruction techniques, enable a fully microscopic and non-perturbative treatment of transport in condensed matter systems, opening the way to quantitative studies of heat conduction in regimes where both anharmonicity and quantum statistics are essential.
[1] Vladislav Efremkin, Stefano Mossa, Jean-Louis Barrat, Markus Holzmann, "Computation of thermal conductivity based on Path Integral Monte Carlo methods", arXiv:2602.16405 |
Giacomo Nasuti - University of Parma
Rare Events and Redundancy in Random Walkers Target Search in a Finite Domain 
Finding a target in a complex environment is a fundamental challenge across natural systems, from chemical reactions to sperm cells reaching an egg. One powerful strategy to reduce search times is redundancy: deploying multiple independent searchers increases the probability of success, particularly when this is driven by rare events. When the underlying stochastic motion features broadly distributed step lengths, rare long relocations dominate the dynamics, making redundancy especially effective.
In this work, we investigate the statistics of extreme events for the mean first passage time in a system of $N$ independent walkers performing power-law-distributed jumps with finite velocity $v$, where target-reaching events are governed by single large fluctuations. We show that the mean first passage time of the fastest walker scales as $1/N$, representing a dramatic speed-up compared to classical Brownian motion, and saturates at the minimum value $X/v$. The model is further extended to include random velocities.
For a fixed $N$, we identify a crossover governed by a critical tail exponent $\alpha_c$, which separates a regime dominated by a single large fluctuation ("big jump") from a regime characterized by Gaussian extreme-value statistics arising from finite sampling effects. From these results, a scaling law linking the number of searchers $N$ to the size $X$ of the search region is derived.
Ultimately, these findings demonstrate how redundancy, combined with rare-event statistics, can efficiently organize target-search processes in complex biological environments. As a prototypical application, we consider mammalian fertilization, deriving a cross-species scaling relation between the number of spermatozoa and the typical uterine size within a coarse-grained description. |
Sarin Nhek - CNR-INO
Coherence in natural and artificial texts 
Long-range coherence is a defining property of written language, persisting across entire books through stable statistical scaling and structured information flow. We show that this property is organized along two nearly orthogonal directions of variability. In this multivariate space, the mean representation of natural books follows a smooth trajectory parameterized by text length.
Using a contemporary LLM with an iterative self-conditioning protocol, we generate long texts that converge toward stable coherence regimes and occupy regions of descriptor space comparable to those of human-written books at similar lengths. Under highly stochastic generation, statistical scaling descriptors remain within natural-text ranges, whereas informational descriptors systematically deviate, indicating a differential robustness across coherence measures.
These results show that contemporary autoregressive language models can reproduce key large-scale statistical structures of written language, while revealing distinct stability regimes governing different aspects of coherence under chaotic generation. |
Alessio Pitteri - Fondazione Bruno Kessler - Università di Bologna
Ant Swarm Functional Control via Stigmergic Reinforcement Learning Agents 
In this work, we investigate the functional controllability of a well-known model of collective behavior: the Ant Swarm Model. We introduce a population of controlling agents, trained via Reinforcement Learning (RL), to influence the dynamics of the system and promote the emergence of ordered behavior. Smart-agents are optimized with Proximal Policy Optimization in a centralized-training decentralized-execution setting, and interact with ants only through the shared pheromone field. The reward design promotes trail pheromone structures and alignment of ant positions with high-pheromone paths, without requiring control of specific microscopic configurations. Our results demonstrate that the learned policies effectively shift the phase transition line that characterizes the global behavior of the system, enabling the formation of organized trails in regimes that are typically dominated by randomness. Compared with both the baseline system and an enhanced-hybrid setup, with equal pheromone reinforcement but no learned policy, our approach yields consistently higher ordering and quality metrics across the phase diagram. This study provides insights into the potential of RL based control strategies for stigmergic systems and contributes to the general understanding of functional controllability in complex systems. |
Fabrizio Rippa - Università della Campania "Luigi Vanvitelli"
Hybrid Voter Model 
We investigate how long-range interactions affect consensus formation in a one-dimensional voter model for opinion dynamics. Agents hold binary opinions and update them through a competition between local nearest-neighbor interactions and long-range social links, whose strength decreases with distance. We show that even a small amount of nonlocal interaction can strongly modify the coarsening process, leading to consensus. Depending on how rapidly long-range links decay, the system displays different collective behaviors: a short-range-like regime with a growing crossover scale, a long-range-dominated regime with modified domain growth, and a regime where complete coarsening is suppressed and the system reaches a stationary state. These results show how sparse nonlocal connections can reshape collective decision-making in social and complex systems. |
Óscar Eduardo Rodríguez Villalba - Università di Parma
Schrödinger-Poisson Equation with Contact Interactions 
We investigate the role of contact interactions in the dynamics of fuzzy dark matter (FDM), modeled through the Schrödinger–Poisson equation. While the $\Lambda$CDM paradigm successfully expl$
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Raffaele Salioni - Università degli Studi dell'Insubria
Adaptive quantum dynamics with the time-dependent variational Monte Carlo method 
Describing the dynamics of quantum many-body systems is a formidable problem in contemporary physics.
Understanding these dynamics is crucial for characterizing non-equilibrium phenomena and for the development of quantum technologies.
The simulation of such systems with variational methods is a promising yet challenging task, especially in regimes where highly expressive ansätze lead to numerical instabilities.
We introduce an extension of the time-dependent variational Monte Carlo (tVMC) method [1] that adaptively controls the expressivity of the variational quantum state during the dynamics.
Our adaptive tVMC (atVMC) [2] approach addresses the ill-conditioned equations of motion arising in overparameterized regimes by selectively evolving only the most relevant parameters at each time step. Relevance is quantified through the local-in-time error (LITE), which measures the deviation between variational and exact evolution, using only quantities already available in standard tVMC simulations.
We benchmark the method on quantum quenches in the one-dimensional transverse-field Ising model using both spin-Jastrow and restricted Boltzmann machine wave functions. The adaptive scheme significantly improves numerical stability and reduces the need for strong regularization, enabling reliable simulations with highly expressive variational ansätze.
[1] G. Carleo, F. Becca, M. Schiró, and M. Fabrizio, Sci. Rep. 2, 243 (2012).
[2] R. Salioni, R. Martinazzo, D.E. Galli, C. Apostoli, Phys. Rev. B 113, 014408 (2026). |
Alessandro Sarracino - Università della Campania "L. Vanvitelli"
The grand canonical catastrophe, revisited 
The realisation of Bose-Einstein condensation of photons under
grand-canonical conditions has provided experimental evidence for the
simultaneous occurrence of macroscopic fluctuations and phase
coherence of the condensate. The observation of these two features,
against a consolidated tradition which wants the fluctuations to be
pathological (grand-canonical catastrophe) and incompatible with
spontaneous symmetry breaking, calls for a comprehensive rethinking of
the approach to the problem. In this talk we consider the uniform
ideal gas in a box and we present an alternative conceptual framework.
We show that the usually-employed Bogoliubov quasi-average
construction fails to reproduce the broken-symmetry state. The
observed features are accounted for by a different pattern of
spontaneous symmetry breaking, characterized by condensation of
fluctuations and long-range correlations of the order parameter. |
Ivan Saychenko - PhD student at Parma
Estimating entanglement between quantum emitters using directional emission 
Recently, it was shown that quantum interference in a system containing a polarized and an unpolarized emitter can allow directional emission of photons into a circulating cavity. Here we ask whether high directionality of photon emission in this system implies a high degree of quantum correlation between the two emitters. We show that the answer is a qualified “yes,” with photon emission directionality and emitter-emitter entanglement showing a monotonic relationship over a broad parameter range. The relationship breaks down only in the limit of perfect directionality. Furthermore, under reasonable assumptions for experimental parameters and stability, we show that the statistics of measured directionality allow a reliable estimate of the concurrence. This result implies that directionality of photon emission in the state preparation stage can be used to determine the entanglement between the emitters, with potential applications to more generic cases including quantum networks. |
Massimiliano Semeraro - CY Cergy Paris Université
Phase Separation Kinetics in a Polar Active Field Model 
Phase separation underlies a broad range of phenomena, from materials science to biological organization, and is commonly characterized by the emergence of universal power laws t^z governing domain-growth evolution. In the present contribution, we present our recent results concerning the investigation of a phase-separating polar active model comprising a scalar density field with an advective coupling to a polarization field, the latter modeling self-propulsion. Our analysis reveals a novel growth regime with exponent z∼0.6, significantly faster than the typical z∼1/3 behavior of conserved systems, and in quantitative agreement with the accelerated growth recently observed in extensive simulations of polar active particles. Combining numerical simulations in two and three dimensions with analytical arguments, we identify the mechanism underlying this accelerated coarsening: self-propulsion facilitates the creation of topological defects and compresses dense domains, thus leading to faster growth. We further demonstrate that the accelerated-growth regime is robust against several model extensions, including additional self-advection of the polarization field and non-equilibrium contributions inspired by well-established field-theoretic models. Overall, our results provide a minimal field-theoretical framework that explains recent observations of polar active particles, opening new perspectives for understanding living systems and designing active materials.
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Luca Smaldone - Università degli studi di Salerno
Ordering kinetics with long-range interactions: interpolating between voter and Ising models 
We study the ordering kinetics of a one-dimensional generalization of the voter model with long-range, power-law interactions, the $p$-voter model. In this model, the agent, or spin, located at a site of a lattice adopts the majority state among $p$ other agents, whose distances $r$ are drawn from a probability distribution $P(r) \propto r^{-\alpha}$.
For $p=2$, the model can be mapped onto the voter model with the same long-range interactions. For $3 \leq p < \infty$, the dynamics belongs to the universality class of the one-dimensional Ising model with long-range coupling $J(r)=P(r)$, quenched to small but finite temperatures. In the limit $p \to \infty$, we observe a crossover to the distinct behavior of the long-range Ising model quenched to zero temperature. |
Samir Suweis - University of Padova
Universal scaling laws link gene-abundance distributions to adaptive expression in diatom communities worldwide 
Marine microbes sustain Earth’s major biogeochemical cycles, yet how they maintain stable ecosystem functions across diverse environments remains unclear. We analyzed metagenomic and metatranscriptomic data from diatom communities sampled during the Tara Oceans global expedition. While gene abundance distributions remain statistically similar across samples, gene expression varies systematically across geographical locations. We show that this global pattern reflects predictable scaling laws \new{that link stable gene abundance reservoir} to functional responses. Global distributions, scaling relationships, and variability among sampling stations are captured by a stochastic model linking gene abundance dynamics to gene expression, which depends on the efficiency of transcription relative to degradation. While colder waters promote higher transcriptional activity and warmer regions show more selective gene usage, we find that transcript abundance increases nonlinearly with unigene richness. This general scaling is captured by our model and suggests that diatom communities balance high expression of core genes with specific functional diversity. These scaling relationships hold consistently across ocean basins, requiring only temperature to predict transcriptional patterns from genetic composition. Our findings reveal how \new{the stability of gene abundance structure in diatoms} ecosystems coexists with transcriptional variability, enabling flexible functional responses.
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Tommaso Tonolo - Gran Sasso Science Institute (GSSI)
Ecological communities on sparse networks: non-Gaussian effects and topological multiple equilibria 
Real ecological communities are characterized by sparse interaction networks, while most analytical results rely on fully connected models. In this work, we investigate how network sparsity shapes ecological communities within a generalized Lotka–Volterra framework with random interactions and demographic noise.
Using methods from statistical physics, in particular the cavity method and Belief Propagation, we obtain an exact characterization of equilibrium properties on sparse networks. We show that sparsity alone induces strong deviations from Gaussianity in species abundance distributions, even when interactions are Gaussian and the system is in a single-equilibrium phase. In particular, abundance distributions become Gamma-like, in agreement with empirical observations.
In addition, we uncover a novel topological multiple-equilibria phase, fundamentally different from that of fully connected models. In this phase, multiple attractors emerge due to extinction-driven fragmentation of the interaction network.
These results highlight network sparsity as a key ingredient for realistic ecological modeling and provide new insight into the structure and stability of complex ecosystems. |
Vincenzo Zimbardo - University of Parma
Kernel Renormalization in Bayesian Deep Neural Networks: the Equivalent Wishart Ansatz in the Proportional Regime 
The scaling limit where both the size of the training set $P$ and the width $N$ of a deep neural network grow at the same rate, the so-called proportional-width regime, has been intensely studied for shallow, single-hidden-layer networks. However, extending these non-perturbative results from shallow architectures to deep non-linear networks has proven very challenging. Here we present a surprisingly effective approximate approach to predict the generalization performance of Bayesian multi-layer perceptrons (MLPs) and of fixed depth $L$ on arbitrary high-dimensional data. We propose an "equivalent Wishart Ansatz" to capture the dominant stochastic fluctuations of the hierarchical empirical kernels of MLPs. This allows us to perform a large deviation analysis for the partition function of MLPs in the proportional limit, expressed in terms of a renormalized NNGP kernel. In this description, even strong representation learning in the proportional limit is encoded in at most $L$ scalar order parameters, determined self-consistently. Extending the approach to convolutional architectures (CNNs), we identify a hierarchical local kernel renormalization mechanism, which allows to quantify more complex data-dependent transformations of the large-width kernel in CNNs due to finite-width effects. We test our effective theory against sampling experiments from the Bayesian posterior of finite deep neural networks with depths $L \sim O(10)$ and $P\sim O(10^3)$ on classic benchmark datasets, finding overall very good agreement together with two distinct types of systematic deviations. |